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16.04.2012 07:00
( Mayo Clinic ) Mayo Clinic researchers have discovered a new class of molecular mutation in various forms of breast cancer, a finding that may shed new light on development and growth of different types of breast tumors.
( University of Toronto ) Evolutionary biologists at the University of Toronto found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations. A study predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes.
( University of Texas Health Science Center at San Antonio ) Cancer is much more likely in the elderly than the young, and their bodies often are less prepared to fight the disease and the side effects of treatment. But researchers at the Cancer Therapy & Research Center at the UT Health Science Center San Antonio show that an aged immune system can combat cancer just as well as a young one if you remove the impediments to a successful immune system defense.
( Ohio State University Medical Center ) Two particular repressor genes in a family of regulatory genes are vital for controlling cell proliferation during development of the placenta. Their absence in stem cells results in a placenta made up of overcrowded and poorly organized cells that cannot properly transport oxygen and nutrients or support normal embryonic development. The study show how these genes control cell proliferation in living animals.
( Journal of Clinical Investigation ) This article includes a summary of research articles to be published by the Journal of Clinical Investigation on April 16th.
( Ohio State University ) Caring for a wife with breast cancer can have a measurable negative effect on men's health, even years after the cancer diagnosis and completion of treatment, according to recent research.
( University of Cincinnati Academic Health Center ) New research at the University of Cincinnati suggests that kidney cancer growth depends on autophagy, a complex process that can provide cells with nutrients from intracellular sources. Researchers say in certain circumstances autophagy can protect tumor cells from chemotherapy, allowing them to survive for long periods of time in a hidden, dormant, metastatic state.
( Columbia University Medical Center ) Researchers have demonstrated that two related enzymes -- phosphoinositide-3 kinase gamma and delta -- play a key role in the development of T-cell acute lymphoblastic leukemia, a highly aggressive childhood leukemia that is difficult to treat. The study also showed that a dual PI3K gamma/delta inhibitor can significantly prolong survival in a mouse model of the disease.
( Cold Spring Harbor Laboratory ) It should be possible to significantly improve the response of common cancers to existing "classical" chemotherapy drugs, say scientists at CSHL, by introducing agents that alter interactions of cancer cells with their immediate surroundings -- the tumor microenvironment.
( Broad Institute of MIT and Harvard ) A research team pursuing one of the most commonly altered genes in cancer has laid a critical foundation for understanding this gene that could point the way toward developing drugs against it. The new research pinpoints compounds that repress MCL1's activity and highlights an important companion gene that predicts if a tumor is dependent upon MCL1 for survival. Together, these tools suggest a path toward new therapeutics directed at MCL1.
( Cell Press ) A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16 in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules.
( JAMA and Archives Journals ) Among patients undergoing chemoradiation therapy (CRT) for head and neck cancer, performing targeted swallowing exercises following CRT is associated with short-term improvement in swallowing function; however, there were no significant differences in swallowing function between the intervention group and controls at nine or 12 months following treatment, according to a report in the April issue of Archives of Otolaryngology - Head & Neck Surgery, a JAMA Network publication.
( JAMA and Archives Journals ) An analysis of Medicare beneficiaries suggests that surgical treatment for nonmelanoma skin cancer increased substantially from 2001 through 2006, primarily due to a doubling in the rate of Mohs micrographic surgery procedures, according to a report published in the April issue of Archives of Dermatology, a JAMA Network publication.
( University of Texas M. D. Anderson Cancer Center ) More than one-third of patients with invasive cancer are undertreated for their pain, with minorities twice as likely to not receive analgesics, according to research from the University of Texas MD Anderson Cancer Center.
15.04.2012 07:00
( International Association for the Study of Lung Cancer ) Screening for lung cancer with low dose CT scans has been shown to save lives. However, research shows that when CT scans reveal nodules in the lungs, it is not cancerous 96 percent of the time. As a result, scientists are looking for ways to more accurately make a diagnosis. One way is by using a CT-guided transthoracic fine needle aspiration.
( International Association for the Study of Lung Cancer ) Scientists say there is an urgent need for research into all aspects of follow-up care in lung cancer. The study presented in the May 2012 issue of the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology focused on different follow-up strategies for patients with lung cancer. After searching the published literature and databases, researchers analyzed four studies and could not determine that one method was preferred over another.
( University of California - San Francisco ) The key to treating one of the most common types of human leukemia may lie within mutations in a gene called FLT3, according to new research led by physician-scientists at the University of California, San Francisco Helen Diller Family Comprehensive Cancer Center.
( International Association for the Study of Lung Cancer ) Previous research has shown that Asian patients with lung cancer are more likely to harbor epidermal growth factor receptor mutations. Furthermore, Asian patients with lung cancer are more likely to be non-smokers than Western patients with lung cancer. Research in the May 2012 issue of the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology goes deeper, investigated genetic factors and smoking exposure in Japanese lung cancer patients.
14.04.2012 07:00
( University of Michigan Health System ) When women at high risk of breast cancer viewed a customized web-based decision guide about prevention options, they were more likely to make a choice about prevention and to feel comfortable with their choice, a new study finds.
13.04.2012 07:00
( NYU Langone Medical Center / New York University School of Medicine ) Neurosurgeons from NYU Langone Medical Center will present research and discuss surgical approaches and use of new technologies to treat neurosurgical conditions at the annual meeting of the American Association of Neurological Surgeons, held April 14-18, 2012 in Miami Beach, FL.
( Journal of the National Cancer Institute ) A DNA repair pathway-focused score has the potential to help determine if first-line platinum based chemotherapy can benefit advanced-stage ovarian cancer patients, according to a study published April 13 in the Journal of the National Cancer Institute.
( Loyola University Health System ) Loyola University Health System's Cardinal Bernardin Cancer Center has received an Outstanding Achievement Award from the Commission on Cancer of the American College of Surgeons.
( Loyola University Health System ) Researchers are reporting surprising findings about a molecule that helps ramp up the immune system in some cases and suppress it in others. The finding eventually could lead to new drugs to regulate the immune system by, for example, revving it up to attack tumor cells or tamping it down to prevent the rejection of transplanted organs.
( University of Miami ) According to a University of Miami study, women who are physically active during treatment have less depression and an enhanced quality of life and report less debilitating fatigue.
12.04.2012 07:00
( Case Western Reserve University ) Researchers at Case Western Reserve University School of Medicine have identified a new mechanism by which colon cancer develops. By focusing on segments of DNA located between genes, or so-called "junk DNA," the team has discovered a set of master switches, i.e., gene enhancer elements, that turn "on and off" key genes whose altered expression is defining for colon cancers. They have coined the term Variant Enhancer Loci or "VELs," to describe these master switches.
( University of North Carolina School of Medicine ) In a paper published today in the journal Cell, a team from the University of North Carolina at Chapel Hill unveils the first broad-based test for activation of protein kinases "en masse", enabling measurement of the mechanism behind drug-resistant cancer and rational prediction of successful combination therapies.
( University of Hull ) Biomarkers which could help to predict resistance to chemotherapy in breast cancer patients have been identified by researchers from the University of Hull, UK.
( IMIM (Hospital del Mar Research Institute) ) Researchers at the Hospital de Mar Research Institute have discovered that the protein LOXL2 has a function within the cell nucleus thus far unknown. They have also described a new chemical reaction of this protein on histone H3 that would be involved in gene silencing, one of which would be involved in the progression of breast, larynx, lung and skin tumors.
11.04.2012 07:00
( SomaLogic, Inc. ) In a paper published in PLoS ONE, researchers from SomaLogic and the University of Washington in Seattle describe the first application of the SOMAscanTM proteomic assay technology to tissue samples. Working with both tumor and non-cancerous lung samples from patients with non-small cell lung cancer, they identified significant expression changes in 36 proteins, including 13 proteins not previously associated with the disease.
( St. Jude Children's Research Hospital ) An international study found that bone marrow transplants are not the best option for some young patients with acute lymphoblastic leukemia who fail to attain clinical remission after the initial weeks of intense chemotherapy known as induction therapy.
( Ludwig Institute for Cancer Research ) Using a powerful DNA sequencing methodology, researchers at the Ludwig Institute for Cancer Research have now investigated the three-dimensional structure of DNA folds in the nucleus of a chromosome. The findings published in the April 11 issue of Nature provide scientists with a greater understanding about the basic principles of DNA folding and its role in gene regulation.
( University of North Carolina School of Medicine ) A UNC-led team of scientists finds that transcription factors don't act like an "on-off" switch, but instead can exhibit much more complex binding behavior.
( University of Missouri-Columbia ) Women undergoing treatment for breast cancer can experience cognitive declines, such as decreased verbal fluency or loss of memory and attention. Often experienced by patients undergoing chemotherapy, the declines have become known as "chemo brain." However, a health psychologist at the University of Missouri says "chemo brain" isn't always to blame.
( Mary Ann Liebert, Inc./Genetic Engineering News ) Childhood cancer survivors are living longer and there is an urgent need for better, more comprehensive ways to evaluate their health-related quality of life and need for psychosocial services.
( European Society for Medical Oncology ) Abstracts submitted to the 3rd European Lung Cancer Conference will be released today (12:00 CEST) and available at http://www.esmo.org/events/lung-2012-elcc/program.html. Detailed results will be presented during the ELCC 2012, 18-21 April 2012 in Geneva, Switzerland.
10.04.2012 07:00
( Life Sciences Discovery Fund ) The Life Sciences Discovery Fund today announced nearly $450,000 in awards to three Washington non-profit organizations to foster commercial translation of new health and health-care products.
( University of Michigan Health System ) A majority of Michigan oncology practices participating in a statewide consortium followed treatment guidelines for common cancers, but had gaps in managing symptoms and end-of-life care, according to a new study.
( Canadian Medical Association Journal ) Cancer is a growing health concern in low- and middle-income countries, and there is an opportunity for Canada to make a significant contribution to help tackle the disease, states an analysis in CMAJ (Canadian Medical Association Journal).
( American Cancer Society ) A new supplement in the journal Cancer outlines an innovative model to address a wide range of physical issues faced by women with breast cancer and offers hope for improved function and full participation in life activities for patients through rehabilitation and exercise.
( IDIBELL-Bellvitge Biomedical Research Institute ) Researchers from the Bellvitge Biomedical Research Institute have shown that breast cancer cells that metastasize to the lung express a higher level of the protein peroxiredoxin 2 The study suggests that the modulation of the levels of this protein could be a new therapeutic strategy to prevent lung metastases. The study results have been published in the online edition of the journal Oncogene.
( Better Health Publishing ) A non-toxic, botanical formula controls aggressive human prostate tumors in mice, according to a peer-reviewed study in the the International Journal of Oncology.
( Wiley-Blackwell ) People who received frequent dental X-rays in the past have an increased risk of developing the most commonly diagnosed primary brain tumor in the United States. That is the finding of a study published early online in Cancer, a peer-reviewed journal of the American Cancer Society. Although dental X-rays are necessary in many cases, these findings suggest that moderate use of this form of imaging may be of benefit to some patients.
09.04.2012 07:00
( Rush University Medical Center ) Results of a large, randomized, controlled trial conducted by Rush University Medical Center scientist Dr. James L. Mulshine, and co-researchers showed that screening with low-dose spiral computed tomography not only reduces lung cancer deaths but would cost insurers less than colorectal, breast and cervical cancer screenings.
( University of Southern California ) The overwhelming majority of cancer patients prefer riskier treatments that offer the possibility of longer survival over safer treatments.
( NYU Langone Medical Center / New York University School of Medicine ) In the current hyper-charged United States healthcare debate, the focus on lowering cost without compromising quality of care remains a priority. But according to a new study by researchers at NYU Langone Medical Center and colleagues, one common approach may have serious unintended consequences.
( JAMA and Archives Journals ) Patients for whom colonoscopy was recommended were less likely to complete colorectal cancer screening than those patients for whom fecal occult blood testing (FOBT) was recommended or those patients who were given a choice between FOBT or colonoscopy, according to a study published in the April 9 issue of Archives of Internal Medicine, a JAMA Network publication.
( New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College ) An international research team led by Weill Cornell Medical College investigators have discovered two inherited-genetic deletions in the human genome linked to development of aggressive prostate cancer. The findings, published online today in the Proceedings of the National Academy of Sciences, indicate a man's risk of developing prostate cancer either triples or quadruples, depending on the genetic variant they inherit.
( American Cancer Society ) A new report by American Cancer Society scientists says new data showing aspirin's potential role in reducing the risk of cancer death bring us considerably closer to the time when cancer prevention can be included in clinical guidelines for the use of aspirin in preventative care.
( University of Pennsylvania School of Medicine ) More than 60 percent of breast cancer survivors report at least one treatment-related complication even six years after their diagnosis, according to a new study led by a researcher from the Perelman School of Medicine at the University of Pennsylvania. The findings are part of a special issue of Cancer devoted to exploring the physical late effects of breast cancer treatment and creating strategies to prevent, monitor for, and treat these conditions in the nation's 2.6 million survivors of the disease.
( Journal of Clinical Investigation ) This press release contains a list and links to the research articles to be published by the Journal of Clinical Investigation on April 9, 2012.
( Massachusetts General Hospital ) Combining two strategies designed to improve the results of cancer treatment - antiangiogenesis drugs and nanomedicines - may only be successful if the smallest nanomedicines are used.
( Elsevier Health Sciences ) Scientists from Duke University Medical Center have determined that genes acting as molecular "on/off" switches can define clinically relevant molecular subtypes of ovarian cancer, providing ideal potential targets for use in clinical prognostic and diagnostic testing. These bimodal genes can define tumor subtypes that have different overall prognoses and respond to different therapeutic regimens. The researchers' results are published in the May issue of the Journal of Molecular Diagnostics.
( Rice University ) Using light-harvesting nanoparticles to convert laser energy into "plasmonic nanobubbles," researchers at Rice University, Baylor College of Medicine and the University of Texas MD Anderson Cancer Center have developed methods for delivering chemotherapy drugs directly into cancer cells. In tests on drug-resistant cancer, the researchers found the methods were up to 30 times more deadly to cancer cells than traditional chemotherapy and required less than one-tenth the clinical dose.
( Mayo Clinic ) Researchers will use tumor and patient genomes to find new therapies and drugs for individual patients.
( American Society of Hematology ) A novel anti-leukemia compound with little toxicity successfully treated zebrafish with T-cell acute lymphoblastic leukemia (T-ALL), suggesting its potential to become a new highly targeted therapy for humans -- even those resistant to conventional therapies -- according to results from a study published online today in Blood, the Journal of the American Society of Hematology (ASH).
08.04.2012 07:00
( Duke University Medical Center ) An international team of scientists, led by researchers from the Duke-NUS Graduate Medical School (Duke-NUS) in Singapore and National Cancer Center of Singapore, has identified hundreds of novel genes that are mutated in stomach cancer, the second-most lethal cancer worldwide.
06.04.2012 07:00
( University of Southern California ) New research from USC on a protein that protects cancer and other cells from oxidative stresses could one day help doctors to break down cancer cells' defenses, making them more susceptible to treatment.
05.04.2012 07:00
( Journal of the National Cancer Institute ) False-positive mammograms could be an indicator of underlying pathology that could result in breast cancer, according to a study published April 5 in the Journal of the National Cancer Institute.
( Journal of the National Cancer Institute ) Women with ductal carcinoma in situ have high rates of diagnostic and invasive breast procedures after treatment with breast-conserving surgery according to a study published April 5 in the Journal of the National Cancer Institute.
( Thomas Jefferson University ) Edith Mitchell, M.D., FACP, a medical oncologist at Jefferson's Kimmel Cancer Center and Clinical Professor of Medicine and Medical Oncology in the Department of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, has been named the 2012 recipient of the American Society of Clinical Oncology Humanitarian Award for her personification of the society's mission and values, and for going above and beyond the call of duty in providing outstanding patient care.
( McGill University ) The earlier breast cancer is detected, the better the chance of successful treatment and long-term survival. However, early cancer diagnosis is still challenging as testing by mammography remains cumbersome, costly, and in many cases, cancer can only be detected at an advanced stage. A team based in McGill University's Faculty of Medicine has developed a new microfluidics-based microarray that could one day radically change how and when cancer is diagnosed.
( Cell Press ) Researchers reporting in the April Cell Stem Cell, a Cell Press publication, have found a way to stop leukemia stem cells in their tracks. The advance in mice suggests that a combination approach to therapy might stamp out chronic myeloid leukemia for good.
( Northwestern University ) Nanotechnology offers powerful new possibilities for targeted cancer therapies, but the design challenges are many. Northwestern University scientists now are the first to develop a nanoparticle that can deliver a drug directly to a cancer cell's nucleus. They also are the first to directly image at nanoscale dimensions how nanoparticles interact with the nucleus, which dramatically changes shape. The researchers found this shape change linked to cells dying and the cell population becoming less viable.
( Karolinska Institutet ) People who are diagnosed with cancer have a markedly increased risk of suicide and cardiovascular death during the period immediately after being given the diagnosis. This has been shown in a new study from Karolinska Institutet in Sweden, published in the prestigious scientific journal the New England Journal of Medicine.
04.04.2012 07:00
( BioMed Central ) American women of African ancestry are more likely than European Americans to have estrogen receptor (ER) negative breast cancer. New research published in BioMed Central's open access journal Breast Cancer Research has shown that specific genetic variations in the vitamin D receptor and in CYP24A1 (responsible for deactivating vitamin D) are associated with an increase in breast cancer risk, particularly for ER negative breast cancer, for African-American women.
( University of Colorado Denver ) Men experience a marked drop in their testosterone levels when taking a targeted therapy to control a specific type of lung cancer.
( Brigham and Women's Hospital ) A team of scientists have found promising effects of a first-in-class targeted cancer drug called BIND-014 in treating solid tumors.
( The Yates Network ) BIND Biosciences published preclinical and clinical data in Science Translational Medicine showing promising effects in solid tumors and successful clinical translation of BIND-014, the first targeted and programmed nanomedicine to enter human clinical studies. The paper describes BIND-014's ability to concentrate in tumors demonstrating efficacy, safety and pharmacological properties that are superior to and highly differentiated from the parent chemotherapeutic drug, docetaxel. BIND-014 is the first clinical-stage targeted therapeutic nanoparticle with programmable pharmacological properties.
( Fred Hutchinson Cancer Research Center ) The first large-scale US-based study to evaluate the link between an injectable form of progestin-only birth control and breast cancer risk in young women has found that recent use of a year or more doubles the risk. The results of the study, led by breast cancer epidemiologist Christopher I. Li, M.D., Ph.D., of Fred Hutchinson Cancer Research Center, are published online ahead of the April 15 print issue of Cancer Research.
( Simon Fraser University ) An international team of scientists, including four at Simon Fraser University, has made a discovery that will change the way the most deadly form of breast cancer is treated. The journal Nature has just published the team's findings online in the paper The clonal and mutational evolution spectrum of primary triple negative breast cancers. The study is the largest genetic analysis of what were thought to be triple negative breast cancer tumors.
( Johns Hopkins Medical Institutions ) A new study by Johns Hopkins researchers shows that obese white women may be less likely than normal-weight counterparts and African-Americans of any weight or gender to seek potentially lifesaving colon cancer screening tests.
( University of Houston ) A new lecture series at the University of Houston will showcase how science is making a difference in health and medicine. The first of five lectures will be held April 25 and is free and open to the public. The first lecture is by Bruce M. Spiegelman of Harvard Medical School, who will discuss a recent discovery of a hormone secreted from muscle cells that triggers key health benefits of exercise.
( European Society for Radiotherapy and Oncology (ESTRO) ) ESTRO 31 and the World Congress of Brachytherapy will combine to feature new research results in clinical and basic radiobiology, physics and brachytherapy, presented by top doctors and scientists from all over the world working together for the benefit of cancer patients.
( The Yates Network ) Data from an ongoing Phase 1 clinical study of BIND-014, the first targeted and programmable Accurin nanomedicine to reach the clinic, demonstrated safety and tolerability, and showed evidence of anti-tumor activity in patients with solid tumor cancers. BIND-014 demonstrated partial response or stable disease in this heavily pretreated patient population with durable responses of up to six months. BIND-014 also demonstrated activity in tumors for which conventional docetaxel is known to have minimal activity.
( Fox Chase Cancer Center ) Inflammatory breast cancer is a very aggressive, often misunderstood type of cancer. The five-year survival rate is between 25 and 50 percent. The reason for the poor prognosis is that IBC usually grows rapidly and often spreads quickly to other parts of the body. Researchers at Fox Chase have developed a new cell and animal model that holds promise for providing a detailed understanding the disease and for developing effective interventions.
( Fox Chase Cancer Center ) When combined with other treatments, the drug cetuximab has been shown to extend survival in certain types of cancer. Unfortunately, about 40 percent of colorectal cancer patients -- specifically those who carry a mutated form of a gene called KRAS -- do not respond to the drug. Researchers at Fox Chase, however, have been working on a way to overcome this resistance by unleashing a second cetuximab driven mechanism using a novel drug called ARI-4175.
( American Association for Cancer Research ) Patients with nonprogressive disease had improved survival rates. 5-year survival rate for stage 3B/4 patients was 50 percent.
( American Association for Cancer Research ) Patients with lung cancer and KRAS mutation responded well to antifolate therapy. Response linked to downregulation of KRAS expression. Downregulation may render cells more susceptible to chemotherapeutic drug.
( NIH/National Institute of Environmental Health Sciences ) Researchers at the National Institutes of Health have discovered how exposure to arsenic can turn normal stem cells into cancer stem cells and spur tumor growth.
( North Shore-Long Island Jewish (LIJ) Health System ) Scientists from the Feinstein Institute for Medical Research will present three abstracts about Glioblastoma multiforme, the most common and deadly adult brain cancer, at the American Association for Cancer Research Annual Meeting to be held from Saturday through Wednesday (March 31- April 4) in Chicago, IL.
( University Hospitals Case Medical Center ) Physician-scientists from University Hospitals Case Medical Center's Seidman Cancer Center and Case Western Reserve University School of Medicine presented new research findings in 24 presentations this week at Annual Meeting of the American Association for Cancer Research.Two innovative studies are investigating novel methods that may help clinicians bring a greater specificity to the treatment of glioblastoma in the future.
03.04.2012 07:00
( Johns Hopkins Medical Institutions ) A team of scientists led by Johns Hopkins researchers have found that more than four in 10 people considered at high risk for hereditary pancreatic cancer have small pancreatic lesions long before they have any symptoms of the deadly disease.
( Cedars-Sinai Medical Center ) Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute is the only cancer center in Los Angeles to receive a Commission on Cancer 2011 Outstanding Achievement Award for providing quality care and services to cancer patients.
( Boston University Medical Center ) Anurag Singh, Ph.D., assistant professor in the Department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine has been invited to present his recent work on targeted therapeutics for colon cancer at the American Association of Cancer Research Annual Meeting in Chicago, Ill. Singh's seminar, scheduled for April 3, will be featured in the "Late-Breaking Abstracts Mini-Symposium." This highlights recent and provocative groundbreaking research in cancer biology.
( Public Library of Science ) Genetic mutations in cancer cells can lead to resistance to treatment, thereby potentially resulting in relapse. However, a new article, published April 3 in the online, open-access journal PLoS Biology, suggests that the converse may also happen. Steven Frank (University of California, Irvine) and Marsha Rosner (University of Chicago) propose that it may often be the case that some cells become resistant before any genetic change, and later acquire the genes to stabilize that resistance.
( Fox Chase Cancer Center ) The hormone estrogen may help promote lung cancer -- including compounding the effects of tobacco smoke on the disease -- pointing towards potential new therapies that target the hormone metabolism, according to new research presented at the AACR Annual Meeting 2012 on Tuesday, April 3 by scientists at Fox Chase Cancer Center in Philadelphia.
( Public Library of Science ) A study in this week's PLoS Medicine suggests that increasing height and, among women who have never taken menopausal hormone therapy, increased body mass index are risk factors for developing ovarian cancer.
( American Association for Cancer Research ) High hormone levels are linked to longer survival regardless of treatment. Biomarker provided a meaningful method for patient stratification. Data should inform future clinical trial design.
( Oncolytics Biotech Inc. ) Trials using a naturally occurring harmless virus show promise in treating head and neck cancer.
( North Shore-Long Island Jewish (LIJ) Health System ) Researchers and doctors at the North Shore-LIJ Health System and the have discovered that blood can help determine the best treatment plan for patients with ovarian cancer.
( JAMA and Archives Journals ) Adding the drug cetuximab to a regimen of drugs used for the treatment of patients following surgery for stage III colon cancer did not result in improved disease-free survival, according to a study in the April 4 issue of JAMA.
( JAMA and Archives Journals ) The addition of a screening ultrasound or magnetic resonance imaging to annual mammography in women with an increased risk of breast cancer and dense breast tissue resulted in a higher rate of detection of incident breast cancers, according to a study in the April 4 issue of JAMA.
( Thomas Jefferson University ) Removing a lipoprotein receptor known as SR-BI may help protect against breast cancer, as suggested by new findings presented at the American Association for Cancer Research Annual Meeting 2012 by Jefferson's Kimmel Cancer Center researchers.
( Northwestern University ) A new drug developed by Northwestern Medicine scientists prevented human prostate cancer cells from spreading to other tissues without any toxic effects. The drug turns off the "go" switch in the cancer cells and immobilizes them. Prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs.
( Thomas Jefferson University ) Hepatitis B-infected patients with significantly longer telomeres -- the caps on the end of chromosomes that protect our genetic data -- were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson's Kimmel Cancer Center at the American Association for Cancer Research Annual Meeting 2012.
( American Association for Cancer Research ) Intake is associated with decreased mortality and recurrence rates. Dose-response relationship was observed. Researchers recommend survivors eat more cruciferous vegetables.
( American Association for Cancer Research ) Fifty-one percent of people who have had cancer died from cancer. Forty-nine percent of cancer survivors died from other conditions. Researchers encourage a more comprehensive approach to survivor health.
( American Association for Cancer Research ) Disease prevalence is similar between Hispanics in Puerto Rico and California. Researchers suggest that biology of disease drives tumor behavior. Expression of estrogen receptor was associated with better prognosis.
( American Association for Cancer Research ) Caffeine and exercise decreased risk for sunlight-caused skin cancers in mice. Results suggest that fat and tumor growth are related. Findings link caffeine and exercise with lower levels of inflammation.
( American Association for Cancer Research ) Risk for prostate cancer recurrence increased as excess body weight increased. Obese and overweight men were at higher risk. Body weight status and related lifestyle factors could be used to predict risk.
( Kaiser Permanente ) Younger girls are more likely than adult women to report side effects after receiving Gardasil, the human papillomavirus vaccine. The side effects are non-serious and similar to those associated with other vaccines, according to a new study funded by the Centers for Disease Control and Prevention and published in the Journal of Women's Health.
( Dana-Farber Cancer Institute ) Scientists at Dana-Farber Cancer Institute have discovered why diabetic-like symptoms develop in some patients given rapamycin, an immune-suppressant drug that also has shown anti-cancer activity and may even slow aging.
( Cell Press ) The drug known as rapamycin is widely used by cancer and transplant patients. But, it also comes with a downside: rapamycin leads to diabetes in as many as 15 percent of the people who take it. Now, researchers reporting in the April Cell Metabolism, a Cell Press publication, have figured out why that is. The drug turns the insulin signal off in muscle, to prevent muscle cells from taking blood sugar in.
( H. Lee Moffitt Cancer Center & Research Institute ) Researchers at Moffitt Cancer Center have carried out a study to validate the utility of new tumor classification systems for staging and predicting relapse-free survival for patients with neuroendocrine tumors and who may be candidates for surgery.
( Lund University ) A current study shows that the risk for coronary heart disease and stroke increases by almost thirty per cent in a person whose partner has cancer. The cause is probably the negative stress to which the cancer patient's relative is exposed.
( Karolinska Institutet ) Esophageal cancer is a very serious form of cancer that, if not fatal, requires extensive surgery. A new study from Karolinska Institutet in Sweden shows that when serious complications arise after surgery for esophageal cancer, many patients suffer other health problems, such as breathlessness, fatigue, insomnia and eating problems, for five years afterward.
( University of Helsinki ) Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki discovered that spontaneous induction of KSHV lytic replication in tumors drastically attenuated the p53-dependent apoptotic response not only to a targeted therapy but also to genotoxic anti-cancer agents.
( Mayo Clinic ) A study presented today by Mayo Clinic researchers at the American Association for Cancer Research Annual Meeting 2012 in Chicago identified two genes that are optimal targets to be analyzed in a new noninvasive test for colorectal cancer developed by Mayo Clinic, in collaboration with Exact Sciences Corporation.
( Mayo Clinic ) The dietary supplement gamma-linoleic acid can inhibit the growth of a subset of pancreatic cancer cells and selectively promote cancer cell death in mice, a Mayo Clinic study has found.
( Johns Hopkins Medical Institutions ) This news tip is based on abstracts and presentations by Johns Hopkins Kimmel Cancer Center scientists scheduled to present their work at the American Association for Cancer Research Annual Meeting 2012, March 31-April 4, in Chicago.
( The Translational Genomics Research Institute ) The feasibility of selecting treatment based on individual molecular characteristics was demonstrated in a first-of-its kind pancreatic cancer clinical trial reported today by the Translational Genomics Research Institute and the Virginia G. Piper Cancer Center at Scottsdale Healthcare.The findings were announced during the American Association for Cancer Research Annual Meeting 2012, March 31-April 4, in Chicago.
( Fox Chase Cancer Center ) Scientists at Fox Chase Cancer Center in Philadelphia have come one step closer to developing the first treatment to target a key pathway in lymphoma. The new findings will be announced at the AACR Annual Meeting 2012 on Tuesday, April 3.
( American Association for Cancer Research ) Nab-paclitaxel and carboplatin yielded a 41 percent response rate. Toxicity of the combination is tolerable.
( American Association for Cancer Research ) Patients did not have to adjust lifestyle or common drugs for this test. Age affected four methylation markers studied, but to different extents. Selecting optimal methylation markers may minimize false positives.
02.04.2012 07:00
( Mayo Clinic ) The combination of the novel drug TH-302 with the standard drug gemcitabine has shown early signs of delaying the worsening of cancer in patients with advanced pancreatic cancer, a Mayo Clinic-led study has found.
( Harvard School of Public Health ) New Harvard School of Public Health research suggests that routine mammography screening -- long viewed as an essential tool in detecting early breast cancers -- may in fact lead to a significant amount of overdiagnosis of disease that would otherwise have proved harmless. Based on a study of women in Norway, the researchers estimate that between 15 percent and 25 percent of breast cancer cases are overdiagnosed.
( Fox Chase Cancer Center ) Scientists at Fox Chase Cancer Center are developing a new way to treat pancreatic cancer by boosting the effects of gemcitabine (Gemzar) -- the chemotherapy drug that is considered standard therapy for the disease. Although gemcitabine is the first line of defense against pancreatic cancer, many cells find ways to evade the treatment. The new research found several compounds that appear to improve the cancer-killing effect of gemcitabine.
( Mary Ann Liebert, Inc./Genetic Engineering News ) When a mother undergoes genetic testing to determine whether she carries a gene for hereditary breast cancer, the parents must then decide whether and how to share this risk information with their children.
( University of California - Los Angeles Health Sciences ) An early Positron Emission Tomography response after the initial cycle of neoadjuvant chemotherapy can be used to predict increased survival in patients with soft tissue sarcomas.
( Centro Nacional de Investigaciones Oncologicas (CNIO) ) Researchers of the Spanish National Cancer Research Center, led by Sagrario Ortega, have created transgenic mice in which, for the first time, the growth of the lymphatic vessels can be visualized in the whole animal, by a light-emitting reaction, as tumor progresses and forms metastasis.
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