Single-Cell Analysis of T-Cell Receptor Repertoire of HTLV-1 Tax-Specific Cytotoxic T Cells in Allog…
29.07.2010, 06:08
This study suggests a basis to understand the efficacy of allogeneic hematopoietic stem cell transplantation as a treatment for…
Multicenter Prospective Study on Efficacy and Safety of Octreotide for Inoperable Malignant Bowel Ob…
26.07.2010, 18:17
Conclusions The high improvement rate in abdominal symptoms suggested the efficacy of octreotide in terminally ill patients wit…
[Articles] Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-…
02.08.2010, 01:00
Results of two phase 3 trials have shown first-line bevacizumab in combination with chemotherapy improves clinical outcomes in …
Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: A Meta-Analy…
21.07.2010, 07:12
(Source: Nutrition and Cancer)
Phase I/II study of the pharmacokinetics, safety, and efficacy of S†1 in patients with advanced he…
27.08.2010, 07:09
(Source: Cancer Science)
Report of a Multicenter Phase II Trial Testing a Combination of Biweekly Bevacizumab and Daily Erlot…
17.07.2010, 00:01
Conclusion Combination chemotherapy with bevacizumab and erlotinib showed clinical activity with infrequent grade 3 and 4 adver…
[Reflection and Reaction] The IAEA-ACC study: a commendable start
01.06.2010, 01:00
Overgaard and colleagues and the International Atomic Energy Agency (IAEA) are to be congratulated for designing a trial—IAEA…
Can we better select patients with metastatic renal cell carcinoma for cytoreductive nephrectomy?
17.05.2010, 01:00
The objective of this study was to identify preoperative factors that were prognostic of outcome in patients who were being con…
Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy o…
31.07.2010, 23:00
This study investigated the anti-CSCC effects of a triterpenoid compound, Cucurbitacin B (CuB). Dose-response studies showed th…
Supratentorial Glioblastoma Treated with Radiotherapy: Use of the Radiation Therapy Oncology Group R…
26.07.2010, 18:17
Conclusions This study confirms the prognostic value of the recursive partitioning analysis grouping. Basal ganglia invasion co…
Intrinsic mitochondrial membrane potential change and associated events mediate apoptosis in chemopr…
06.08.2010, 14:12
Authors: Kaur J, Sanyal SN The present study explored the role of intrinsic mitochondrial membrane potential (delta psi M) in N…
[Articles] Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemo…
02.08.2010, 01:00
Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodi…
[Reflection and Reaction] Beyond steroid hormones: the new cancer endocrinology
01.06.2010, 01:00
The meta-analysis by the Endogenous Hormones and Breast Cancer Collaborative Group of studies investigating the relation betwee…
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for non…
21.08.2010, 09:43
Conclusions: Final analysis of AVAiL confirms the efficacy of bevacizumab when combined with cisplatin–gemcitabine. The PFS ben…
Novel classification based on immunohistochemistry combined with hierarchical clustering analysis in…
03.08.2010, 01:00
Somatostatin analogues ameliorated many symptoms caused by neuroendocrine tumors (NET), but their antitumor activities are limi…
Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurre…
23.07.2010, 14:14
Abstract We evaluated the efficacy of temozolomide (TMZ) or lomustine (CCNU) in combination with 6-thioguanine, capecitabine, a…
Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multi…
28.07.2010, 16:46
Conclusion: Ipilimumab demonstrated clinical activity with encouraging long-term survival in a previously treated advanced mela…
Loading, high-dose fulvestrant regimens do not improve efficacy
24.08.2010, 07:20
Increasing the approved dose of fulvestrant does not appear to improve the efficacy of treatment for recurrent breast cancer, r…
Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analy…
29.07.2010, 02:40
Authors: Jiang L, Yang KH, Tian JH, Guan QL, Yao N, Cao N, Mi DH, Wu J, Ma B, Yang SH Several studies have evaluated the possib…
Efficacy, biodistribution, and pharmacokinetics of CD22-targeted pegylated liposomal doxorubicin in …
15.05.2010, 01:00
CONCLUSION: IL-PLD has increased efficacy without increased toxicity compared with PLD. This suggests that IL-PLD may be an imp…
Siltuximab, a Novel Anti-Interleukin-6 Monoclonal Antibody, for Castleman's Disease [Hematologic Mal…
07.08.2010, 00:02
Conclusion These interim results strongly suggest that siltuximab is an effective treatment with favorable safety for the manag…
Association of a vascular endothelial growth factor gene 936 C/T polymorphism with breast cancer ris…
23.07.2010, 13:10
Abstract Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism a…
A Microfluidic Platform for Systems Pathology: Multiparameter Single-Cell Signaling Measurements of …
29.07.2010, 06:08
This study describes a microfluidic imaging technology that can enhance pathological analysis of tumor biopsies. (Source: Cance…
Supporting informed decision making online in 20 minutes: an observational web-log study of a PSA te…
29.08.2010, 14:30
CONCLUSIONS: Increased usage of Prosdex leads to more informed decision making, the key aim of the UK Prostate Cancer Risk Mana…
Transplanting Normal Vascular Proangiogenic Cells to Tumor-Bearing Mice Triggers Vascular Remodeling…
29.07.2010, 06:08
This study describes a microfluidic imaging technology that can enhance pathological analysis of tumor biopsies. (Source: Cance…
Human papillomavirus infection and sporadic breast carcinoma risk: a meta-analysis
26.08.2010, 10:14
Abstract Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the assoc…
Lenalidomide efficacy in bortezomib-resistant myeloma
28.08.2010, 07:12
Authors: Alessandro Gozzetti, Rosaria Crupi, Marzia Defina & Monica Bocchia We read with great interest the Case Study by Ludwi…
A phase II and pharmacokinetic study of first line S-1 for advanced gastric cancer in Taiwan
16.08.2010, 20:02
Conclusions The efficacy, toxicity and pharmacokinetic profiles of S-1 in current study are compatible with those from other As…
New Views into the Prostate Cancer Genome
13.07.2010, 05:00
Lloyd Trotman, Scott Powers. Genomic analysis of prostate cancer has not answered key clinical questions such as “Which tumor…
[Articles] Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre,…
01.06.2010, 01:00
First-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) is usually limited to four to six cycles. Maintenance t…
Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory …
17.07.2010, 00:01
Conclusion These results confirm the poorer prognosis of obese women with early-stage breast cancer. Recurrence rates were lowe…
FLANG salvage chemotherapy is an effective regimen that offers a safe bridge to transplantation for …
17.08.2010, 08:01
Abstract The efficacy of fludarabine in combination with an intermediate dose of cytosine arabinoside, mitoxantrone, and G-CSF …
Matched Pair Analysis Comparing Surgery Followed By Radiotherapy and Radiotherapy Alone for Metastat…
30.07.2010, 00:01
Conclusion In this study, the outcomes of the end points evaluated after radiotherapy alone appeared similar to those of surger…
Testicular cancer risk associated with occupational radiation exposure: a systematic literature revi…
27.08.2010, 01:00
Authors: Yousif L, Blettner M, Hammer GP, Zeeb H Testicular cancer is a rare disease, affecting mainly young men aged 15-49. Th…
New adenovirus induces response
30.07.2010, 07:12
Nature Reviews Clinical Oncology 7, 422 (2010). doi:10.1038/nrclinonc.2010.109 Author: Lisa Hutchinson The antitumor efficacy o…
Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma …
27.08.2010, 01:00
Conclusion: We have demonstrated the utility of the application of integrated analysis using high resolution CGH and whole geno…
Determination of the methylation status of MGMT in different regions within glioblastoma multiforme
23.07.2010, 14:14
This study was designed to assess the methylation status of the MGMT promoter in different areas of GBM and determine if methyl…
A multicenter international randomized phase III study comparing cisplatin in combination with irino…
21.08.2010, 09:43
Conclusions: Our data demonstrate the noninferiority of IP versus EP for survival in primarily Western patients with SCLC-ED. A…
Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with gli…
04.08.2010, 22:46
Abstract Epigenetic silencing of the O6-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated w…
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and…
15.05.2010, 01:00
CONCLUSION: The MTD of BIBF 1120 in combination with standard-dose pemetrexed was 200 mg bid. Continuous daily treatment with B…
A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in pa…
17.05.2010, 01:00
Conclusions: Low dose cyclophosphamide treatment followed by GV1001 vaccinations did not show antitumor efficacy as per tumor r…
Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and fami…
30.07.2010, 19:03
Abstract Glycodelin (encoded by PAEP gene) is a secreted lipocalin protein mainly expressed in reproductive tissues, but also i…
Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis inclu…
12.07.2010, 01:00
Conclusions: This study combined transcriptomic and lipidomic approaches to establish that sulfatides are elevated in ovarian c…
Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidat…
23.07.2010, 13:10
Abstract The aim of this study is to test the hypothesis that antiangiogenic treatment with sunitinib consolidation can prolong…
Intensity modulated radiation therapy or stereotactic fractionated radiotherapy for infratentorial e…
20.08.2010, 07:47
This study was to evaluate the treatment dosimetry, efficacy and toxicity of intensity modulated radiation therapy (IMRT) and f…
[Reflection and Reaction] GPC5 and lung cancer in multiple sclerosis
02.08.2010, 01:00
We read with interest the recent genome-wide association study by Li and colleagues and the identification of single nucleotide…
Coping strategies used by children hospitalized with cancer: an exploratory study
26.07.2010, 01:00
Conclusions: Findings from this study indicated that children use different coping strategies at different developmental stages…
Audit of patients with mesothelioma treated with pemetrexed in a single institution in Western Austr…
28.07.2010, 01:00
Malignant pleural mesothelioma (MPM) is a devastating malignancy that until recently has had no effective treatment. Pemetrexed…
Drugs used to treat osteoporosis not linked with higher risk of esophageal cancer
10.08.2010, 06:00
(JAMA and Archives Journals) Although some reports have suggested a link between the use of oral bisphosphonates (drugs that pr…
Limited resection followed by intraoperative seed implantation is comparable to stereotactic body ra…
22.07.2010, 01:00
The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachythe…
Body mass index and waist circumference are predictor biomarkers of breast cancer risk in Iranian wo…
27.07.2010, 11:29
In this study, we examined the ability of body mass index (BMI) and waist circumference (WC) as predictor biomarkers of breast …
Targeted therapies: Biomarkers in NSCLC for selecting cetuximab therapy
30.07.2010, 07:12
Authors: Thomas E. Stinchcombe & Mark A. Socinski A phase III trial investigated the efficacy of carboplatin and a taxane with …
[Reflection and Reaction] Safety and efficacy of denosumab in giant-cell tumour of bone
01.06.2010, 01:00
In the March, 2010, issue of The Lancet Oncology, Thomas and colleagues describe the safety and efficacy of denosumab in patien…
Four-dimensional dosimetry validation and study in lung radiotherapy using deformable image registra…
29.05.2010, 01:00
This study validates the 4D Monte Carlo dosimetry with measurement, compares 4D dosimetry of different tumor sizes and tumor mo…
microRNA Expression Profiling of Side Population Cells in Human Lung Cancer and Preliminary Analysis
13.07.2010, 07:13
Conclusion miRNA may play important roles in tumorigenesis of lung cancer stem cell. The study of miRNA contributes to elucidat…
DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of…
01.09.2010, 06:07
This study represents one of the first methylome interrogation studies in MM and points toward global hypomethylation at genic …
[Articles] Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk sof…
01.06.2010, 01:00
The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the acti…
[News] 12th World Congress on Gastrointestinal Cancer
02.08.2010, 01:00
In the RADIANT-3 study, a randomised, placebo-controlled phase 3 trial, James Yao (Houston, TX, USA) and colleagues assessed th…
Is Statin Use Really Associated With Efficacy of Rituximab? [CORRESPONDENCE]
19.08.2010, 00:01
(Source: Journal of Clinical Oncology)
Fluorescence resonance energy transfer biosensors for cancer detection and evaluation of drug effica…
31.07.2010, 21:42
Authors: Lu S, Wang Y A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutan…
ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen recept…
27.07.2010, 01:00
Conclusions: We anticipate that free web applications, such as ImmunoRatio, will make the quantitative image analysis of ER, PR…
Intra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma
02.06.2010, 01:00
Hepatic artery administration of iodine-131-Lipiodol serves as a modality that delivers targeted radiation therapy to hepatocel…
Comparison of cisplatin- and carboplatin-based third-generation chemotherapy in 1,014 Chinese patien…
27.07.2010, 11:29
Abstract The outcome of patients with stage IIIB/IV non-small-cell lung cancer treated with platinum-based chemotherapy as firs…
Multimodal exercise improves quality of life of women being treated for breast cancer, but at what c…
23.08.2010, 19:58
Abstract To evaluate the efficacy and economic efficiency of a multimedia, multimodal physical activity program for women under…
Virtual colonoscopy catches more, study finds
22.08.2010, 15:26
Now, a new study suggests that virtual colonoscopy may even be superior because it can identify cancers outside of the colon.08…
Development of a novel poly bisphosphonate conjugate for treatment of skeletal metastasis and osteop…
31.07.2010, 23:05
This study describes the development of a new polybisphosphonate conjugate (ODX) with enhanced dual efficacy i.e. with anti-bon…
A practical approach to manage additional lesions at preoperative breast MRI in patients eligible fo…
23.07.2010, 13:09
Abstract The aim of this prospective study was to evaluate the efficacy of directives, established to handle additional lesions…
Does Bevacizumab Improve Outcomes in Advanced Ovarian Cancer?
03.06.2010, 17:54
Dr. Maurie Markman previews the findings of the latest Gynecologic Oncology Group study as well as a provocative but preliminar…
Chemotherapy of advanced small-bowel adenocarcinoma: a multicenter AGEO study
21.08.2010, 09:43
Conclusions: This is the largest study of chemotherapy in advanced SBA. Baseline PS and CEA and CA 19-9 levels were the main pr…
Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-sma…
15.05.2010, 09:59
Conclusions The recommended dose for phase II/III studies is 18.4 mg/m2 of BNP7787 in combination with paclitaxel and cisplatin…
Restoration of Gefitinib Efficacy Following Chemotherapy in a Patient with Metastatic Non-Small Cell…
24.07.2010, 07:08
Onkologie 2010;33:11 (DOI:10.1159/000319109) (Source: Karger Publishers)
Clinical array-based karyotyping of breast cancer with equivocal HER2 status resolves gene copy numb…
28.07.2010, 01:00
Conclusions: These results illustrate the analytical power of array-based genomic analysis as a clinical laboratory technique f…
A pediatric phase I trial and pharmacokinetic study of ispinesib: A Children's Oncology Group phase …
14.08.2010, 07:12
(Source: Pediatric Blood and Cancer) MedWorm Message: Register for MedMatcha, MedWorm's medical advertising network , and recei…
Efficacy of the InVance™ Male Sling in Treating Stress Urinary Incontinence: A Three-Year Exper…
14.07.2010, 01:00
Urol Int (DOI:10.1159/000314918) (Source: Karger Publishers)
Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma
30.05.2010, 01:00
This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlati…
Brain metastases from colorectal carcinoma: prognostic factors and outcome
14.05.2010, 11:23
The objectives of this study are to assess the natural history, outcome, and possible prognostic factors in CRC patients with b…
FDG-PET in the assessment of patients with follicular lymphoma treated by ibritumomab tiuxetan Y 90:…
21.08.2010, 09:43
Conclusions: RIT is an effective therapy in FL patients, as confirmed in our study too. Disease extension before treatment and …
Cellular Adaptive Immune System Plays a Crucial Role in Trastuzumab Clinical Efficacy [CORRESPONDENC…
17.07.2010, 00:01
(Source: Journal of Clinical Oncology)
Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined wit…
23.08.2010, 01:00
Authors: S Zenvirt, N Kravchenko-Balasha & A Levitzki (Source: Oncogene)
Genetically Abnormal Circulating Cells in Lung Cancer Patients: An Antigen-Independent Fluorescence …
22.07.2010, 01:00
CONCLUSIONS: We have developed a sensitive and quantitative antigen-independent FISH-based test for detecting CACs in periphera…
Genetic variants in selenoprotein genes increase risk of colorectal cancer
28.05.2010, 23:43
This study analysed 12 single-nucleotide polymorphisms (SNPs) in selenoprotein genes [glutathione peroxidase 1 (GPX1), GPX4, 15…
Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
19.08.2010, 18:38
Abstract To establish the prognostic value of B7-H4 expression by tumor cells in gastric cancer patients, we evaluated the asso…
Lymphedema beyond breast cancer
27.07.2010, 01:00
Secondary lymphedema is a debilitating, chronic, progressive condition that commonly occurs after the treatment of breast cance…
Efficacy and Safety of Micafungin as an Empirical Antifungal Agent for Febrile Neutropenic Patients …
21.07.2010, 01:00
Acta Haematol 2010;124:92–97 (DOI:10.1159/000315558) (Source: Karger Publishers)
Palonosetron for the prevention of chemotherapy-induced nausea and vomiting in glioblastoma patients…
14.05.2010, 11:21
Conclusion A single dose of palonosetron before the initiation of multiple oral doses of TMZ, in patients on treatment with ste…
MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma …
28.05.2010, 23:43
This study aimed to investigate the action of miR-34a on cell invasion. We found that miR-34a is expressed at various levels in…
Effect of dietary intake of isoflavones on the estrogen and progesterone receptor status of breast c…
29.07.2010, 02:39
Authors: Zhang M, Liu X, Holman CD To examine if higher intake of isoflavones prior to diagnosis was associated with a positive…
Major Study Complicates Debate Over Cell Phone Use and Cancer Risk
18.05.2010, 07:15
Results from a major international study do not establish a definitive link between cell phone use and cancer, but they don't r…
Adherence with oral chemotherapy: results from a qualitative study of the behaviour and representati…
23.07.2010, 01:00
This study was carried out in two specialist cancer centres. The results showed a wide diversity in the prescribers' practices,…
Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and…
26.08.2010, 20:13
Abstract Anti-angiogenic agents targeting brain tumor neovasculature may increase progression-free survival in patients with re…
Androgen receptor status predicts response to chemotherapy, not risk of breast cancer in Indian wome…
04.08.2010, 01:00
The objectives of this study were to characterize AR-CAG repeat genotypes in a cohort of women with breast cancer and to determ…
Largest study of genomes and cancer treatments releases first results
15.07.2010, 06:00
(Wellcome Trust Sanger Institute) The largest study to correlate genetics with response to cancer drugs releases its first resu…
Breast Cancer Staging Should Include Breast MRI, Study Suggests
14.05.2010, 02:00
Breast magnetic resonance imaging (MRI) can detect breast lesions missed on mammography and ultrasound and help surgeons plan t…
Association of Choline Levels and Tumor Perfusion in Brain Metastases Assessed with Proton MR Spectr…
17.07.2010, 22:06
Authors: Huang BY, Kwock L, Castillo M, Smith JK While malignant brain tumors typically show high choline concentrations and ne…
TNFRSF1B A1466G genotype is predictive of clinical efficacy after treatment with a definitive 5-fluo…
20.07.2010, 01:00
In this study, genetic polymorphisms of TNFRSF1B gene were evaluated Japanese esophageal squamous cell carcinoma (ESCC) patient…
Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study
20.08.2010, 19:02
Abstract The adjuvant use of aromatase inhibitors in breast cancer is associated with adverse effects on bone health. We previo…
Gene Expression-Based Approaches in Differentiation of Metastases and Second Primary Tumour.
29.08.2010, 14:30
Authors: Vooder T, Välk K, Kolde R, Roosipuu R, Vilo J, Metspalu A A 64-year-old male patient was diagnosed with 3 consecuti…
Nicotine Can Fuel Breast Cancer, Study Suggests
25.08.2010, 09:00
Title: Nicotine Can Fuel Breast Cancer, Study SuggestsCategory: Health NewsCreated: 8/24/2010 12:10:00 PMLast Editorial Review:…
Analysis of the genome to personalize therapy for melanoma
09.08.2010, 01:00
Authors: M A Davies & Y Samuels (Source: Oncogene)
Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastat…
04.08.2010, 14:50
The phosphoinositide-3 kinase (PI3K)–AKT– mammalian target of rapamycin (mTOR) pathway is an important cellular pathway control…
Monitoring the Effect of Docetaxel Treatment in MCF7 Xenografts Using Multimodal In Vivo and Ex Vivo…
09.08.2010, 11:12
Authors: Huuse EM, Jensen LR, Goa PE, Lundgren S, Anderssen E, Bofin A, Gribbestad IS, Bathen TF The purpose of this study was …
A Polymorphic Variant of AFAP-110 Enhances cSrc Activity.
09.08.2010, 11:12
In this report, we analyzed ovarian cancer tissues for the expression of a cSrc-activating protein, AFAP-110. AFAP-110 activate…
Recent Knowledge of the Relationship Between Helicobacter pylori and Gastric Cancer and Recent Progr…
24.08.2010, 08:19
Gastric cancer is a multi-step process and multi-factorial disease. However, Helicobacter pylori plays the most important role …
Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteom…
01.09.2010, 06:07
In this study, we analyzed the insulin-like growth factor (IGF-1) signaling network in the MDA-MB231 breast cancer cell line. W…
Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas
19.07.2010, 01:00
This study was designed to investigate EGFR protein expression, EGFR copy number and EGFR mutations in lung adenocarcinomas, to…
Phase II study of biweekly S-1 and oxaliplatin combination chemotherapy in metastatic colorectal can…
23.08.2010, 19:55
Conclusions Biweekly S-1 with oxaliplatin is effective and has improved tolerability and convenience compared to other fluoropy…
Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma
01.09.2010, 01:00
The objective of this study was to determine the level of Bmi-1 expression or its autoantibodies in human esophageal squamous c…
An open cohort study of bone metastasis incidence following surgery in breast cancer patients
21.07.2010, 01:00
Background: To help design clinical trials of adjuvant bisphosphonate therapy for breast cancer, the temporal incidence of bone…
New Study Finds HPV Vaccine Protects Against Genital Warts
21.07.2010, 09:00
Title: New Study Finds HPV Vaccine Protects Against Genital WartsCategory: Health NewsCreated: 7/20/2010 8:10:00 PMLast Editori…
What is the meaning of palliative care in the Asia-Pacific region?
23.07.2010, 01:00
This paper describes the preliminary work required to understand cultural differences in palliative care in the United Kingdom …
Sex chromosome changes after sex-mismatched allogeneic bone marrow transplantation can mislead the c…
28.05.2010, 01:00
A 12-year-old male with pre-B-cell acute lymphoblastic leukemia with cryptic BCR/ABL rearrangement underwent sex-mismatched all…
Maternal and paternal lineage double heterozygosity alteration in familial breast cancer: a first ca…
20.08.2010, 19:02
Abstract Hereditary breast cancer syndrome was firstly associated with BRCA1 and BRCA2 genes the mutations of which confer high…
Interventions to Promote Repeat Breast Cancer Screening With Mammography: A Systematic Review and Me…
20.07.2010, 22:02
(Source: JNCI)
Polymorphism in exon 4 of TP53 gene associated to HPV 16 and 18 in Mexican women with cervical cance…
27.07.2010, 11:29
Abstract Cervical cancer (CC) is the second most common cancer in Mexican women. Human papillomavirus (HPV) infection is necess…
Phase II Study of the Anti-Cytotoxic T-Lymphocyte-Associated Antigen 4 Monoclonal Antibody, Tremelim…
17.07.2010, 00:01
Conclusion Tremelimumab did not demonstrate clinically meaningful single-agent activity in this patient population, although th…
New Breast Cancer Study Findings Recently Were Published By E. Vanriel And Co-Researchers
28.05.2010, 02:00
This study explores knowledge about hereditary breast cancer, attitudes about BRCA testing and referral pattern to a family can…
[Reflection and Reaction] Regional hyperthermia: new standard for soft-tissue sarcomas?
01.06.2010, 01:00
In this issue of The Lancet Oncology, Issels and colleagues describe a large, randomised phase 3 study assessing the effects of…
Comparative Analysis by Chromosome Painting of the Sex Chromosomes in Arvicolid Rodents
30.07.2010, 01:00
Cytogenet Genome Res (DOI:10.1159/000318012) (Source: Karger Publishers)
Anticancer effect of a novel 2-arylidene-4,7-dimethyl indan-1-one against human breast adenocarcinom…
06.08.2010, 14:12
Authors: Prasanna R, Harish CC A novel compound 2-arylidene-4,7-dimethyl indan-1-one synthesized was screened for anticancer ef…
Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with hu…
31.07.2010, 23:01
In this study, we investigated mRNA expression in adrenal tumors of transgenic mice and compared them with human pheochromocyto…
Broccoli Component Limits Breast Cancer Stem Cells, U-M Study Finds
28.05.2010, 02:00
A compound derived from broccoli could help prevent or treat breast cancer by targeting cancer stem cells -- the small number o…
An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation wi…
04.08.2010, 14:50
Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the do…
Phase II, Open-Label Study of Pazopanib or Lapatinib Monotherapy Compared With Pazopanib Plus Lapati…
30.07.2010, 00:01
Conclusion This study confirms the activity of antiangiogenesis agents in advanced and recurrent cervical cancer and demonstrat…
Postoperative Neurological Deficit after Carotid Endarterectomy: A Mid-Term Outcome Analysis
23.07.2010, 01:00
Cerebrovasc Dis 2010;30:297–301 (DOI:10.1159/000319073) (Source: Karger Publishers)
The combined contribution of social support and coping strategies in predicting post-traumatic growt…
03.06.2010, 01:00
Conclusions: This study contributes to a deeper understanding of the type of social support that may specifically aid cancer pa…
Study Suggests Painters Face Increased Risk of Bladder Cancer
21.07.2010, 09:00
Title: Study Suggests Painters Face Increased Risk of Bladder CancerCategory: Health NewsCreated: 7/20/2010 12:10:00 PMLast Edi…
Is Mandatory Biopsy in Clinical Trials Justifiable?
13.07.2010, 22:09
Dr. Kathy Miller weighs the ethical concerns about requiring biopsies to participate in breast cancer clinical trials against t…
A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastati…
01.09.2010, 17:58
Serum interleukin (IL)-6 levels correlate with disease outcomes in renal cell carcinoma (RCC) patients. Siltuximab, a chimeric,…
Prevalence of daily medication adherence among children with sickle cell disease: A 1†year retrosp…
09.08.2010, 10:15
Abstract (Source: Pediatric Blood and Cancer)
CMS Shocks Pharma
20.07.2010, 14:00
As covered in the RPM Report, CMS announced June 30 that it had opened a national coverage analysis (NCA) for Provenge to deter…
Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: a …
18.08.2010, 19:42
This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of ad…
Iron-regulating protein is strong predictor of breast cancer prognosis, study shows
04.08.2010, 06:00
(Wake Forest University Baptist Medical Center) A new study by researchers at Wake Forest University Baptist Medical Center may…
Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comp…
13.08.2010, 01:00
Conclusions: These results indicate that MCC may not actually play any causative role in early colorectal tumorigenesis. We als…
CCND1 G870A polymorphism and cervical cancer risk: a case–control study and meta-analysis
15.05.2010, 10:03
Conclusion The G870A polymorphism in CCND1 may not contribute to the etiology of cervical cancer in Chinese populations. Conten…
A quantitative meta†analysis of neurocognitive sequelae in survivors of pediatric brain tumors
09.08.2010, 10:15
Abstract (Source: Pediatric Blood and Cancer)
Lilly Presents New Data In Advanced Melanoma - A Difficult-To-Treat Cancer That Causes Majority Of S…
29.05.2010, 02:00
Lilly released results today from a Phase II study evaluating Lilly Oncology's tasisulam, a novel anti-cancer agent, in patient…
AACR 2009- Study of the extra cellular matrix around cancer cells and 3D assays
14.07.2010, 01:06
Dr Mina Bissell, Lawrence Berkeley National Laboratory, USA, speaking at AACR 2009: Study of the extra cellular matrix around c…
Skin and Nail Responses after 1 Year of Infliximab Therapy in Patients with Moderate-to-Severe Psori…
13.07.2010, 01:00
Dermatology (DOI:10.1159/000317775) (Source: Karger Publishers)
Epirubicin, Oxaliplatin, and Capecitabine With or Without Panitumumab for Advanced Esophagogastric C…
31.08.2010, 00:02
Conclusion The recommended dose for EOC + P is epirubicin 50 mg/m2, oxaliplatin 100 mg/m2, capecitabine 1,000 mg/m2/d, and P 9 …
Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial c…
20.07.2010, 01:00
Conclusions: EBT shows acute results similar to HDR brachytherapy. Additional research is needed to further assess the clinical…
Plasma and urinary alkylresorcinol metabolites as potential biomarkers of breast cancer risk in finn…
29.07.2010, 02:39
Authors: Aubertin-Leheudre M, Koskela A, Samaletdin A, Adlercreutz H Alkylresorcinols (ARs) are shown to be good biomarkers of …
ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung ca…
14.05.2010, 11:36
This study was to investigate whether the expressions of DNA repair genes ERCC1 (excision repair cross complementing 1), RRM1 (…
Citalopram effective in managing hot flashes
27.07.2010, 07:14
Good efficacy and minimal toxicity make citalopram a candidate for managing hot flashes associated with tamoxifen use, accordin…
Phase II study on the addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) to doceta…
15.05.2010, 01:00
CONCLUSION: The study met some endpoints (prostate-specific antigen response, tumor response) but not others (i.e., time to tum…
Study Shows Cancer May Be Detected By Your Breath
10.08.2010, 01:00
A new study, published in the British Journal of Cancer, has shown that cancer may be detected through a person's breath. Even …
Higher doses of anastrazole required in overweight breast cancer patients
21.07.2010, 07:13
The relative efficacy of anastrozole compared with tamoxifen is greater in postmenopausal women with a healthy weight than in t…
A Prospective Randomized Study of the Radiotherapy Volume for Limited-stage Small Cell Lung Cancer: …
13.07.2010, 07:13
Background and objective Controversies exists with regard to target volumes as far as thoracic radiotherapy (TRT) is concerned …
Research News: Ovary removal proves beneficial for BRCA mutation carriers
01.09.2010, 01:00
BRCA mutation carriers who opt for surgery survive longer than those forgoing the operation. Surgical removal of the ovaries l…
Comparison of Two Standard Chemotherapy Regimens for Good-Prognosis Germ Cell Tumors: Updated Analys…
17.08.2010, 22:04
Conclusion The survival benefit of 3B90E500P over 4B30E360P was maintained with long-term follow-up. (Source: JNCI)
Sorafenib for Recurrent Hepatocellular Carcinoma After Liver Transplantation
26.07.2010, 18:17
Conclusions These findings suggest that sorafenib may be a feasible treatment option regarding its efficacy and safety for recu…
Is advanced renal cell carcinoma becoming a chronic disease?
20.08.2010, 14:16
Cora Sternberg and colleagues 1 reported the efficacy of the multitargeted receptor tyrosine kinase inhibitor pazopanib for the…
Poor Breast Cancer Survival in Blacks May Not Be Due to Race
16.07.2010, 02:00
Many factors, including access to health care, could affect outcome, analysis finds (Source: Cancercompass News: Breast Cancer)
Neural Network Analysis to Predict Mortality in End-Stage Renal Disease: Application to United State…
01.06.2010, 01:00
Nephron Clin Pract 2010;116:c148–c158 (DOI:10.1159/000315884) (Source: Karger Publishers)
Identifying research priorities and research needs among health and research professionals in psycho…
01.08.2010, 01:00
Conclusion: This is the first Australian study to explore research priorities in psycho-oncology, and the first international s…
Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated …
31.07.2010, 21:42
CONCLUSIONS: JS1/34.5-/47-/GM-CSF combined with cisplatin-based chemoradiotherapy is well tolerated in patients with SCCHN. The…
High-dose-rate Intracavitary Brachytherapy Combined with External Beam Radiotherapy for Stage IIIb A…
26.07.2010, 18:17
Conclusions The 5-year overall survival rate of stage IIIb adenocarcinoma of the uterine cervix in this retrospective questionn…
Study Data From Mayo Clinic, Department Of Radiation Oncology Provide New Insights Into Breast Cance…
28.05.2010, 02:00
Current study results from the report, 'In newly diagnosed breast cancer, screening MRI of the contralateral breast detects mam…
Clinical Investigation of Efficacy of Pemetrexed in 32 Patients with Pulmonary Adenocarcinoma after …
13.08.2010, 07:19
Conclusion Pemetrexed was clinically beneficial for the patients with pulmonary adenocarcinoma after the failure of chemotherap…
Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence
21.08.2010, 09:43
Conclusion: The weight of the evidence indicates there are circumstances in which volumetric image analysis adds value to clini…
A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastati…
31.08.2010, 01:00
A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer British…
Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppress…
13.07.2010, 01:00
Conclusions: Collectively, all results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated p…
Nutrients and risk of prostate cancer.
29.07.2010, 02:40
This study assesses the association between intake of protein, fats, cholesterol, and carbohydrates and the risk of prostate ca…
Study: Prostate cancer patients' weight linked to tumor size
02.06.2010, 06:00
(Henry Ford Health System) The size of tumors in prostate cancer patients is directly linked to their weight, according to a ne…
Outcome analysis of patients with transformed teratoma to primitive neuroectodermal tumor
21.08.2010, 09:43
Conclusions: PNET of GCT origin is associated with an adverse outcome. For low-volume disease, surgery is the optimal initial t…
Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone
29.08.2010, 01:00
Conclusion: Our findings suggest that bisphosphonates may be useful in controlling disease progression in GCTB and that these a…
Analysis of Oestrogen Regulation of Alpha-, Beta- and Gamma-Secretase Gene and Protein Expression in…
03.06.2010, 14:44
Neurodegenerative Dis (DOI:10.1159/000282279) (Source: Karger Publishers) MedWorm Message: Register for MedMatcha, MedWorm's me…
Radiation-induced changes in peripheral nerve by stereotactic radiosurgery: a study on the sciatic n…
23.07.2010, 14:14
This study was to evaluate the radiation-induced changes of sciatic nerve treated by stereotactic radiosurgery (SRS) in rabbit.…
Cancer incidence in the multicenter aids cohort study before and during the HAART era
30.07.2010, 01:00
The incidence of Kaposi sarcoma (KS) and non-Hodgkin lymphoma (NHL) among human immunodeficiency virus (HIV)-infected individua…
Safety Analysis of Ambulatory Chemotherapy in Lung Cancer
13.07.2010, 07:13
Conclusion Ambulatory chemotherapy is a favorable way to promote. (Source: Chinese Journal of Lung Cancer)
Regional and seasonal influence in patient’s toxicity to adjuvant chemotherapy for early breast ca…
27.08.2010, 19:15
Abstract Results from multinational clinical trials are globally adopted into the routine clinical practice in most countries. …
GST Polymorphisms Interact With Dietary Factors to Modulate Lung Cancer Risk: Study in a High-Incide…
29.07.2010, 02:39
Authors: Gervasini G, Jose CS, Carrillo JA, Benitez J, Cabanillas A The aim of this study was to explore possible correlations …
Adult T-cell leukemia/lymphoma in Taiwan: An analysis of 17 patients and review of the literature
02.08.2010, 01:00
Conclusion: ATL in Taiwan is a rare malignant T-cell lymphoma with a very poor prognosis. Our series raised the interesting pos…
A prospective study of nonfunctioning pituitary adenomas: presentation, management, and clinical out…
20.08.2010, 19:01
Abstract A prospective study was performed to evaluate the presentation, therapeutic management, and clinical outcome of nonfun…
Targeting the dynamic HSP90 complex in cancer
24.07.2010, 07:07
Authors: Jane Trepel, Mehdi Mollapour, Giuseppe Giaccone & Len Neckers The molecular chaperone heat shock protein 90 (HSP90) ha…
Genetic variation in RNASEL associated with prostate cancer risk and progression
31.08.2010, 17:33
Variation in genes contributing to the host immune response may mediate the relationship between inflammation and prostate carc…
Variations in the quality and costs of end-of-life care, preferences and palliative outcomes for can…
02.08.2010, 01:00
DiscussionCollecting data on end-of-life care retrospectively from bereaved relatives has ethical, practical and scientific cha…
Lymphoma Survivors Often Miss Out on Follow-Up
16.07.2010, 02:00
Many aren't being screened for later cancers, study finds (Source: Cancercompass News: Breast Cancer)
No evidence for an association of human papillomavirus and breast carcinoma
23.08.2010, 19:58
This study aims to evaluate the expression of HPV 6, 11, 16, and 18 by polymerase chain reaction (PCR) in invasive ductal breas…
A community-based approach to cancer counselling for patients and carers: a preliminary study
03.06.2010, 01:00
Objective: The delivery of psychological care services to people with cancer and their carers is a key clinical priority that h…
Coffee and tea consumption and endometrial cancer risk in a population-based study in New Jersey
14.05.2010, 11:26
Abstract We evaluated the role of tea and coffee and substances added (sugar/honey, creamers, and milk) on endometrial cancer r…
Uncertainty, lack of control and emotional functioning in women with metastatic breast cancer: a rev…
14.08.2010, 07:10
WARREN M. (2010) European Journal of Cancer Care (Source: European Journal of Cancer Care)
Influence of iMRI-Guidance on the Extent of Resection and Survival of Patients with Glioblastoma mul…
17.07.2010, 22:06
Authors: Senft C, Franz K, Blasel S, Oszvald A, Rathert J, Seifert V, Gasser T Intraoperative MRI (iMRI) is used in glioma surg…
Hematology: Is thalidomide combination a new option for myeloma?
30.07.2010, 07:12
Nature Reviews Clinical Oncology 7, 425 (2010). doi:10.1038/nrclinonc.2010.86 Author: Antonio Palumbo Ongoing investigation int…