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19.04.2012 17:12
GENEVA (MedPage Today) -- Limiting upfront erlotinib (Tarceva) to patients with mutations in the drug's target resulted in significant improvement in progression-free survival in non-small cell lung cancer, a post-hoc analysis of a randomized trial showed.
19.04.2012 02:14
(MedPage Today) -- Giving combination chemotherapy at the same time as radiation can reduce recurrence in bladder cancer patients, researchers found.
19.04.2012 01:07
(MedPage Today) -- Medicare beneficiaries with early-stage kidney cancer appear to fare better with partial nephrectomy rather than radical surgery, a large, observational study showed.
18.04.2012 22:05
(MedPage Today) -- American investor Warren Buffett likely can bank on a cure for his early-stage prostate cancer, experts say.
18.04.2012 18:55
(MedPage Today) -- Trastuzumab prolonged survival among women with HER2-positive early breast cancer, but the benefits were accompanied by significant risks of cardiotoxicity, a systematic review found.
18.04.2012 16:02
(MedPage Today) -- Adding bevacizumab (Avastin) to chemotherapy didn't prolong life for seniors with advanced non-small cell lung cancer (NSCLC), researchers found.
18.04.2012 01:30
(MedPage Today) -- The use of opium is associated with a sharply increased risk of death, particularly among women, a study out of Iran found.
17.04.2012 19:49
(MedPage Today) -- For prostate cancer patients, intensity-modulated radiation therapy (IMRT) may offer better disease control with fewer adverse effects than standard radiation therapy, but proton therapy won't provide additional benefits, researchers found.
17.04.2012 00:44
(MedPage Today) -- Swallowing exercises during radiation and chemotherapy for head and neck cancer help preserve function early on, a small clinical trial showed.
16.04.2012 23:00
(MedPage Today) -- Treatment of nonmelanoma skin cancer using the tissue-sparing Mohs procedure has doubled among the Medicare population in the past decade, particularly among patients in their 60s.
15.04.2012 00:00
(MedPage Today) -- People with motor neuron diseases such as Huntington's disease seem to be protected against cancer, researchers reported.
14.04.2012 00:26
(MedPage Today) -- A favorable gene-expression profile predicted more than a twofold improvement in 5-year survival for patients with ovarian cancer, investigators reported.
14.04.2012 00:01
(MedPage Today) -- The long-sought tobacco component responsible for causing the oral cancers seen with smokeless products may finally have been isolated. Also this week: a new way to boost the host's immune attack on HIV.
13.04.2012 21:29
(MedPage Today) -- GAITHERSBURG, Md. -- An FDA advisory panel unanimously voted in favor of an automated ultrasound device for breast cancer screening after a negative mammogram in women with dense breasts.
13.04.2012 21:02
(MedPage Today) -- This week's topics include comparative effectiveness of urinary incontinence treatments, EKG abnormalities and what they predict, red meat and mortality, and improving colorectal screening compliance.
12.04.2012 00:28
(MedPage Today) -- If initial chemotherapy fails to bring acute lymphoblastic leukemia into remission, the best choice for additional therapy may depend on whether the disease is B-cell or T-cell, researchers found.
11.04.2012 20:31
(MedPage Today) -- The U.S. Preventive Services Task Force, in a draft statement, reaffirmed that ovarian cancer screening for most women does more harm than good and that clinicians should discourage it.
11.04.2012 01:54
(MedPage Today) -- Two germ-line variants have emerged as significant risk factors for prostate cancer development and progression, data from a large cohort study showed.
10.04.2012 22:54
(MedPage Today) -- Recent evidence suggests it will not be long before low-dose aspirin is included in recommendations for preventing cancer, researchers argued.
10.04.2012 16:45
(MedPage Today) -- Using CT scans to screen older smokers who are at risk for lung cancer appears to be as cost-effective as several other common screening studies, researchers found.
10.04.2012 07:01
(MedPage Today) -- Frequent exposure to dental x-rays correlated with a twofold increase in the risk of meningioma, investigators reported.
09.04.2012 23:01
(MedPage Today) -- Patients were less compliant with screening for colorectal cancer when colonoscopy was the only testing option they were given, according to a community-based study.
09.04.2012 18:04
(MedPage Today) -- Genetic variation in the vitamin D pathway might be part of the reason African-American women tend to have more aggressive breast cancer than those of European ancestry, researchers reported.
09.04.2012 07:01
(MedPage Today) -- Drinking alcohol was associated with an increased risk of benign breast disease in adolescent women that may not be alleviated with increased folate intake, researchers found.
08.04.2012 17:00
(MedPage Today) -- Gemtuzumab ozogamicin delivered better event-free and overall survival than standard chemotherapy in previously untreated acute myeloid leukemia.
06.04.2012 23:57
(MedPage Today) -- Fewer cycles of an intensive chemotherapy regimen for advanced Hodgkin's lymphoma improves outcomes and reduces toxicity, researchers found.
06.04.2012 23:54
(MedPage Today) -- A woman's height and body mass index may significantly influence her ovarian cancer risk, a large meta-analysis found.
06.04.2012 23:04
(MedPage Today) -- Women with ductal carcinoma in situ who opt to preserve the affected breast face continued diagnostic and invasive procedures potentially for years after surgery, researchers found.
06.04.2012 21:03
CHICAGO (MedPage Today) -- Patients with advanced lung cancer exceeded survival expectations when treated with a vaccine made from genetically modified human cancer cell lines, long-term follow-up data showed.
06.04.2012 20:30
(MedPage Today) -- A docetaxel-carrying nanoparticle targeted directly to tumor cells appears to have some effects on disease in early human trials, researchers said.
06.04.2012 19:04
CHICAGO (MedPage Today) -- Men with castration-resistant prostate cancer experienced better outcomes when treated with the antifungal itraconazole.
06.04.2012 18:08
(MedPage Today) -- This week's topics include video to promote organ donations, mammography 'plus' for breast cancer diagnosis, and a possible link between a common antibiotic and detached retinas.
06.04.2012 00:25
(MedPage Today) -- A false-positive finding on mammography points to a greater chance of breast cancer long-term, a population-based study suggested.
05.04.2012 22:22
CHICAGO (MedPage Today) -- Patients with advanced and metastastic cancers had "unexpected 5-year survival" when treated with an inexpensive maintenance immunotherapy that boosted levels of natural killer cells, investigators reported here.
05.04.2012 16:14
CHICAGO (MedPage Today) -- High-grade gliomas in children have shown evidence of responsiveness to a vaccine developed from glioma-associated antigens, according to a small study reported here.
05.04.2012 02:01
(MedPage Today) -- Actual body weight should be used to calculate a chemotherapy dose for adults with cancer, regardless of obesity status, according to a new guideline.
05.04.2012 01:35
CHICAGO (MedPage Today) -- A chemotherapy doublet showed promise in patients with advanced non-small-cell lung cancer of squamous histology, according to a study reported here.
05.04.2012 00:00
(MedPage Today) -- Receiving a cancer diagnosis can take an immediate and major toll on a patient, both mentally and physically, a Swedish study suggested.
04.04.2012 21:34
WASHINGTON (MedPage Today) -- The FDA has alerted healthcare professionals that foreign sellers are marketing an inactive, counterfeit version of bevacizumab, approved in the U.S. under the brand name Avastin.
04.04.2012 21:27
(MedPage Today) -- Nine specialty groups have listed tests and treatments that are frequently overused, such as antibiotics for sinus attacks and CT scans for low back pain, in the first phase of a long-term project.
04.04.2012 20:25
SAN DIEGO (MedPage Today) -- The failure to restart statins after head and neck surgery is associated with an elevated risk for death and other cardiovascular adverse outcomes.
(MedPage Today) -- Infections preceded slightly more than half of hospitalizations for venous thromboembolism in a study of older individuals, and blood transfusions were another common predictor, researchers found.
04.04.2012 18:01
(MedPage Today) -- Metal particles shed from metal-on-metal hip replacements don't appear to cause cancer over the midterm, a British registry determined.
04.04.2012 01:01
(MedPage Today) -- Making ultrasound or MRI part of the annual mammography regimen boosts breast cancer detection in women with dense breasts who are at elevated risk, but also increases false positives, a clinical trial affirmed.
04.04.2012 00:13
(MedPage Today) -- Cetuximab plus standard chemotherapy did not fare better than chemotherapy alone in patients with stage III resected colon cancer.
03.04.2012 01:16
CHICAGO (MedPage Today) -- Whole-genome sequencing will provide little useful information for individual risk-assessment, a study of genetics' predictive accuracy for 24 diseases suggested.
03.04.2012 00:24
(MedPage Today) -- Mammography screening leads to a "substantial amount of overdiagnosis" of nonfatal breast cancer, researchers reported.
02.04.2012 21:41
CHICAGO (MedPage Today) -- Long-term hormonal therapy, whether current or previous, significantly increased a woman's risk of invasive breast cancer, data from a large cohort study showed.
02.04.2012 18:36
CHICAGO (MedPage Today) -- High-risk human papillomavirus infection persisted significantly more often in young African-American women than in white women, suggesting an explanation for the increased cervical cancer risk in African Americans, investigators reported here.
02.04.2012 07:16
(MedPage Today) -- More young adults, and females in particular, are presenting with cutaneous melanoma, but overall and disease-specific survival have improved over time.
02.04.2012 00:03
CHICAGO (MedPage Today) -- Many older women with newly diagnosed breast cancer might safely avoid adjuvant radiation therapy, according to a study reported here.
02.04.2012 00:01
CHICAGO (MedPage Today) -- Refractory urothelial cancer had meaningful responses in the majority of patients treated with the angiogenesis inhibitor pazopanib, results of a small clinical trial showed.
01.04.2012 21:00
(MedPage Today) -- Using trastuzumab to deliver a chemotherapy agent directly to cancer cells appeared to work in a phase III clinical trial. Also this week: failure for mesalamine in diverticulitis and delay for a new COPD drug.
01.04.2012 03:14
CHICAGO (MedPage Today) -- Men with castration-resistant prostate cancer had biochemical responses to treatment with an investigational androgen receptor modulator, data from a preliminary clinical trial showed.
31.03.2012 00:00
(MedPage Today) -- The dengue virus is not just a passive rider in mosquitoes, but may actually induce them to feed more aggressively. Also in this week's Lab Notes: high-fat, high-carb diets are bad for the obese rat heart.
30.03.2012 21:31
(MedPage Today) -- The monoclonal antibody ipilimumab (Yervoy) appears to have some activity in melanoma patients with brain metastases, particularly when these lesions are small and patients are asymptomatic, researchers said.
30.03.2012 01:46
(MedPage Today) -- Cancer incidence and mortality have continued the decline that started in the early 1990s, according to an annual report from four major health organizations.
29.03.2012 23:29
SAN FRANCISCO (MedPage Today) -- A minimally invasive procedure that uses electrical pulses to target cancer cells may help make surgery an option for unresectable, locally advanced pancreatic cancer patients, researchers said here.
29.03.2012 22:58
AUSTIN, Texas (MedPage Today) -- A rapid transition from open to minimally invasive surgery for hysterectomy failed to reduce costs at one large medical center, investigators reported here.
29.03.2012 21:27
SAN FRANCISCO (MedPage Today) -- A low-dose protocol may help lessen the amount of radiation that patients having a lung nodule biopsy are exposed to, while still maintaining image quality, researchers said here.
29.03.2012 20:27
WASHINGTON (MedPage Today) -- The FDA has approved a test that screens a donor's blood and blood components for antibodies to viruses that can cause leukemia and neurologic diseases.
29.03.2012 18:02
CHICAGO (MedPage Today) -- Modestly lower LDL levels may indicate higher risk of developing cancer, researchers found in observational data, although causality is questionable.
29.03.2012 00:29
(MedPage Today) -- A federal appeals court has refused to reconsider a 2011 ruling that declared it legal to pay people to donate hematopoietic stem cells.
28.03.2012 21:49
SAN FRANCISCO (MedPage Today) -- Cryoablation of metastatic breast cancer tumors in the liver, kidney, lung, and soft tissues appears safe and may be a cost-effective means of managing the disease, researchers said here.
28.03.2012 19:27
AUSTIN, Texas (MedPage Today) -- Patients with platinum-resistant ovarian cancer had a twofold increase in progression-free survival when treated with an investigational folate conjugate, a randomized trial showed.
28.03.2012 18:32
AUSTIN, Texas (MedPage Today) -- The prevalence of infection with cancer-causing strains of human papillomavirus declined among women during the period that coincided with the introduction of HPV vaccine, investigators reported here.
28.03.2012 00:05
WASHINGTON (MedPage Today) -- The FDA has approved peginesatide (Omontys), a synthetic erythropoiesis-stimulating agent, for treatment of anemia in adult dialysis patients with chronic kidney disease.
27.03.2012 23:00
(MedPage Today) -- Adjuvant imatinib (Gleevec) treatment given for a longer period of time was superior to therapy for only a year following surgery for gastrointestinal stromal tumors, an open-label study found.
27.03.2012 22:00
AUSTIN, Texas (MedPage Today) -- Increasingly severe obesity drives up complication rates after hysterectomy, and outcomes continually worsen with rising body mass index, according to results from a study reported here.
27.03.2012 20:23
AUSTIN, Texas (MedPage Today) -- Patients with relapsed, platinum-sensitive ovarian cancer had almost a twofold improvement in progression-free survival with PARP-inhibitor maintenance therapy, investigators reported.
27.03.2012 18:38
AUSTIN, TEXAS (MedPage Today) -- Patients with advanced endometrial cancer had less toxicity without sacrificing anticancer activity when they received an anthracycline-free chemotherapy doublet, according to a study reported here.
26.03.2012 21:41
AUSTIN, Texas (MedPage Today) -- As use of robotic surgery has proliferated, so have hospitals' unsubstantiated marketing claims for the procedures, investigators reported here.
26.03.2012 20:47
WASHINGTON (MedPage Today) -- The U.S. Supreme Court declined Monday to hear a tobacco company's appeal of a verdict by which it would have to pay $28.3 million to the widow of a smoker who died of lung cancer.
26.03.2012 20:28
(MedPage Today) -- Not all young women receiving fertility-threatening cancer treatments have had equal access to counseling or preservation services, researchers found.
26.03.2012 16:30
AUSTIN, TEXAS (MedPage Today) -- Almost 100% of patients with locally advanced cervical cancer had complete responses to chemoradiation with erlotinib and cisplatin, results of a small clinical trial showed.
25.03.2012 21:00
(MedPage Today) -- Breast cancer patients with a high percentage of dense tissue in their breasts are at greater risk for recurrence. This and other reports from the European Breast Cancer Conference in Vienna are featured this week.
25.03.2012 20:30
AUSTIN, Texas (MedPage Today) -- Patients with locally advanced cervical cancer did not benefit from the addition of a radiation sensitizer to standard chemoradiation.
24.03.2012 00:02
(MedPage Today) -- An increased number of chromosomes with a specific type of abnormality that prevents cancer cells from repairing their DNA may prove useful in predicting the response to cisplatin in breast cancer, researchers reported.
22.03.2012 22:00
(MedPage Today) -- Lumpectomy for ductal carcinoma in situ should aim for wide margins to keep recurrence risk low even if the woman is getting radiotherapy, according to the conclusions of a heavily criticized meta-analysis.
22.03.2012 21:57
(MedPage Today) -- Melanoma of the female genitalia continues to have an unfavorable prognosis, particularly thicker lesions that are not amenable to surgery, according to data from one of the largest clinical series ever reported.
22.03.2012 19:16
(MedPage Today) -- Democratic members of Congress are investigating drug wholesalers who, they said, appear to have used fake pharmacies to obtain cancer drugs in short supply, selling them later at huge markups.
21.03.2012 21:03
WASHINGTON (MedPage Today) -- An FDA advisory committee has tepidly endorsed vincristine sulfate liposomal injection (Marqibo) to treat adults with a rare type of acute lymphoblastic leukemia.
21.03.2012 01:27
WASHINGTON (MedPage Today) -- An FDA advisory committee is recommending approval of one soft-tissue sarcoma drug while rejecting a second agent.
21.03.2012 00:30
(MedPage Today) -- Regular aspirin use leads to significant reductions in the risk of cancer, metastasis, and cancer mortality, according to one of the largest-ever analyses of published data.
20.03.2012 21:49
WASHINGTON (MedPage Today) -- FDA reviewers raised questions about the efficacy of a cancer drug to treat a rare type of acute lymphoblastic leukemia in adults.
20.03.2012 00:53
WASHINGTON (MedPage Today) -- A federal appeals court has upheld the FDA's authority to regulate tobacco products, including a requirement that cigarette makers emblazon their products with graphic warning images.
18.03.2012 18:00
WASHINGTON (MedPage Today) -- A familiar conundrum awaits an FDA advisory committee that will meet Tuesday to consider whether two different drugs should be approved for soft-tissue sarcoma.
18.03.2012 16:00
(MedPage Today) -- New agents and new combinations of agents have added to the options for treating relapsed and refractory multiple myeloma patients, as Stan Gerson, MD, of Case Medical Center tells North American correspondent Michael Smith in this exclusive video report.
16.03.2012 00:12
(MedPage Today) -- Acute myeloid leukemia (AML) arises from "founding clones" of cells that cause myelodysplastic syndromes, suggesting that targeted therapies should be directed at mutations in the original clones, investigators reported.
15.03.2012 22:21
WASHINGTON (MedPage Today) -- The Department of Health and Human Services unveiled an ad campaign Thursday featuring stark -- and often gruesome images -- of former smokers talking about what life is like with a smoking-related disease.
15.03.2012 19:04
(MedPage Today) -- Seeing a cancer specialist may improve survival for women with gynecological cancers, researchers found.
15.03.2012 16:57
(MedPage Today) -- Changes in smoking behavior that started in the mid-1950s averted hundreds of thousands of lung cancer deaths from 1975 to 2000, researchers reported.
15.03.2012 01:01
(MedPage Today) -- Women ages 21 to 29 should undergo cervical cancer screening with Pap tests every three years and then every five years with Pap and HPV tests until age 65, according to updated clinical guidelines.
14.03.2012 23:00
(MedPage Today) -- The controversy over prostate cancer screening seems likely to continue, after the publication of extended follow-up from a major European trial that continues to show a benefit.
(MedPage Today) -- More than 40% of patients had complete clearance of actinic keratosis during treatment with an investigational topical agent, pooled data from four placebo-controlled trials showed.
13.03.2012 23:09
(MedPage Today) -- In Ontario, hospitals that spent the most provided the best patient outcomes, researchers found.
13.03.2012 22:44
(MedPage Today) -- A genetic mutation may help determine the disease course of neuroblastoma in children, researchers found.
12.03.2012 06:01
(MedPage Today) -- Men had a 15% lower risk of prostate cancer if they had been circumcised before first sexual intercourse, data from two case-control studies showed.
10.03.2012 19:47
(MedPage Today) -- Reproductive-age cancer patients had a much higher likelihood of discussing the fertility implications of treatment with a radiation oncologist or medical oncologist than with a surgical oncologist, a national survey showed.
10.03.2012 00:20
(MedPage Today) -- The secrets of an herbal medicine's mechanism of action revealed in this week's Lab Notes. Also, interrupting the pain pathway and welcoming gorillas as close genetic cousins.
09.03.2012 21:54
(MedPage Today) -- A growing population of cancer survivors faces an increased risk of radiation-related second malignancy and cardiovascular disease for which little clinical guidance has emerged, researchers found.
09.03.2012 15:27
(MedPage Today) -- The use of oral or injectable hormone contraceptives is associated with an increased -- though temporary -- risk of breast and cervical cancer, a South African study found.
08.03.2012 23:56
(MedPage Today) -- About 20% of patients with Cushing's disease achieved normalization of urinary free-cortisol levels when treated with the investigational somatostatin analog pasireotide, researchers found.
08.03.2012 20:07
WASHINGTON (MedPage Today) -- More than 3.6 million kids smoke cigarettes, according to a new report from the surgeon general on the scope and health consequences on tobacco use among youth.
08.03.2012 17:55
ORLANDO (MedPage Today) -- Mepolizumab, an investigational humanized monoclonal antibody, is a steroid-sparing treatment that is well tolerated over the long term for patients with hypereosinophilic syndrome, a researcher reported here.
07.03.2012 23:59
(MedPage Today) -- Tumors examined in a laboratory exhibited far more heterogeneity in mutations than previously recognized, suggesting that personalized-medicine strategies based on a single biopsy underestimate cancer's ability to evolve, adapt, and resist treatment, investigators reported.
07.03.2012 21:50
WASHINGTON (MedPage Today) -- There's not enough evidence to support using fecal DNA tests to screen for colorectal cancer in the average-risk person, according to results of a study commissioned by the Department of Health and Human Services.
07.03.2012 20:16
ORLANDO (MedPage Today) -- Two more groups reported here that the anti-IgE biologic drug omalizumab (Xolair) was helpful in speeding immunotherapy for allergies, suggesting that the approach may be gaining momentum.
07.03.2012 00:30
(MedPage Today) -- Reduced breast cancer risk with use of estrogen-only hormone therapy after hysterectomy persists long term, researchers affirmed in an analysis of the Women's Health Initiative trial.
06.03.2012 20:36
(MedPage Today) -- Many primary care physicians in the U.S. accept misleading statistics as proof that cancer screening saves lives, a survey showed.
06.03.2012 00:18
(MedPage Today) -- Colorectal cancer screening should begin at age 50 for all average-risk individuals, according to a new clinical guideline from the American College of Physicians (ACP).
05.03.2012 21:00
(MedPage Today) -- Integration of targeted therapies such as anti-angiogenic agents and PARP inhibitors into treatment regimens can move patients with advanced ovarian cancer off the clinical plateau when response to systemic therapy stalls. MD Anderson's Alpa Nick, MD, discussed the strategy with staff writer Charles Bankhead in this exclusive video report.
02.03.2012 23:42
(MedPage Today) -- Women with screen-detected cervical cancer had a 26% absolute increase in the cure rate as compared with women who were symptomatic at diagnosis, results of a Swedish study showed.
02.03.2012 23:24
(MedPage Today) -- The scourge of malaria just might be tamed by bone drugs given long lipid tails. Also, "Mighty Mouse" and healing the thymus in this week's installment of Lab Notes.
01.03.2012 21:27
WASHINGTON (MedPage Today) -- A federal judge has sided with tobacco companies and ruled that requiring cigarette packages to carry graphic health warnings on their labels is a violation of the tobacco companies' First Amendment rights.
01.03.2012 18:19
(MedPage Today) -- Two new enzyme replacement drugs for patients with pancreatic deficiencies were approved by the FDA on Thursday.
01.03.2012 15:59
(MedPage Today) -- Cancer deaths appear to be falling in Europe, although the figure is projected to be a still-substantial 1.3 million in 2012, researchers found.
29.02.2012 23:03
(MedPage Today) -- The kinase inhibitor ruxolitinib (Jakafi) alleviates spleen enlargement and other symptoms of the bone marrow disease myelofibrosis, but with a questionable impact on survival, two randomized trials showed.
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